Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 79)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0984472	0.0998195	0.3352373
Weighted median	23	-0.0673958	0.0557476	0.2266834
Inverse variance weighted	23	-0.0522067	0.0390153	0.1808610
Simple mode	23	-0.0696833	0.0945874	0.4690838
Weighted mode	23	-0.0743455	0.0695387	0.2966046

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.07519	21	0.8191600
Inverse variance weighted	15.32848	22	0.8477598

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0028396	0.0056423	0.6200084

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005187	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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