Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 789)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0656425	0.0998199	0.5179330
Weighted median	23	0.0152849	0.0579864	0.7920923
Inverse variance weighted	23	0.0253408	0.0390156	0.5160121
Simple mode	23	0.0010806	0.1017386	0.9916211
Weighted mode	23	-0.0019049	0.0752202	0.9800246

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.87630	21	0.4665208
Inverse variance weighted	21.85689	22	0.4684581

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0055873	0.0056423	0.3333262

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006751	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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