Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 788)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1294005	0.1044319	0.2289827
Weighted median	23	0.0533749	0.0545824	0.3281350
Inverse variance weighted	23	0.0261590	0.0409600	0.5230519
Simple mode	23	-0.0232753	0.0905783	0.7995951
Weighted mode	23	0.0689682	0.0646692	0.2977722

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.98508	21	0.3447744
Inverse variance weighted	24.24768	22	0.3343815

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0063401	0.005903	0.2949918

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007484	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8