Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 787)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0625590	0.0998206	0.5376011
Weighted median	23	0.0346411	0.0527675	0.5115117
Inverse variance weighted	23	0.0270470	0.0390156	0.4881625
Simple mode	23	-0.0568685	0.0934898	0.5492272
Weighted mode	23	0.0897854	0.0701127	0.2136756

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.64432	21	0.7892907
Inverse variance weighted	15.79370	22	0.8259907

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0021808	0.0056424	0.7030119

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004931	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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