Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 786)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1220650	0.1045183	0.2559436
Weighted median	23	-0.1040902	0.0607256	0.0865089
Inverse variance weighted	23	-0.0939399	0.0399940	0.0188314
Simple mode	23	0.0042852	0.1104901	0.9694129
Weighted mode	23	-0.1293610	0.0810409	0.1247002

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.02439	21	0.3426792
Inverse variance weighted	23.11810	22	0.3950868

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017272	0.005908	0.7728889

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008762	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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