Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 785)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0226393	0.1003283	0.8236536
Weighted median	23	0.0205645	0.0636256	0.7465357
Inverse variance weighted	23	-0.0170153	0.0390152	0.6627505
Simple mode	23	0.0208048	0.1218409	0.8659779
Weighted mode	23	0.0532071	0.0980252	0.5927318

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.21498	21	0.4458841
Inverse variance weighted	21.40126	22	0.4960721

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0024352	0.0056711	0.6720001

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006543	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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