Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 784)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0467003	0.1017773	0.6510570
Weighted median	23	0.1026546	0.0618045	0.0967221
Inverse variance weighted	23	0.0467590	0.0390152	0.2307298
Simple mode	23	0.1538133	0.1034657	0.1513095
Weighted mode	23	0.1299674	0.0777556	0.1087911

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.83199	21	0.4092465
Inverse variance weighted	21.83199	22	0.4699544

Test for directional horizontal pleiotropy

egger_intercept	se	pval
3.6e-06	0.005753	0.9995061

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007051	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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