Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 783)

Date: 22 April, 2022

Results from two sample MR:

method nsnp b se pval
MR Egger 23 -0.0343552 0.1063042 0.7497562
Weighted median 23 -0.0303914 0.0582297 0.6017243
Inverse variance weighted 23 -0.0020675 0.0406997 0.9594863
Simple mode 23 -0.0733036 0.1046098 0.4908150
Weighted mode 23 -0.0334972 0.0688882 0.6315951

Heterogeneity tests

method Q Q_df Q_pval
MR Egger 23.81692 21 0.3020134
Inverse variance weighted 23.94042 22 0.3503604

Test for directional horizontal pleiotropy

egger_intercept se pval
0.0019828 0.0060088 0.7446846

Test that the exposure is upstream of the outcome

snp_r2.exposure snp_r2.outcome correct_causal_direction steiger_pval
0.0357937 0.0007255 TRUE 0

Note - R2 values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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