Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 782)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1330703	0.1016126	0.2044838
Weighted median	23	0.0435336	0.0575928	0.4497174
Inverse variance weighted	23	0.0316472	0.0415699	0.4464776
Simple mode	23	0.0543953	0.0966368	0.5792057
Weighted mode	23	0.0247848	0.0599958	0.6835249

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.76118	21	0.4133826
Inverse variance weighted	24.97518	22	0.2982632

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0101152	0.0057436	0.0927719

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007767	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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