Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 781)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1151120	0.0998206	0.2617904
Weighted median	23	0.0774546	0.0552207	0.1607250
Inverse variance weighted	23	0.0840215	0.0390155	0.0312763
Simple mode	23	0.0181852	0.0869836	0.8363214
Weighted mode	23	0.0594459	0.0627665	0.3538773

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	9.815219	21	0.9812126
Inverse variance weighted	9.929721	22	0.9869308

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019093	0.0056424	0.7384354

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004414	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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