Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 780)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0486456	0.1077544	0.6562939
Weighted median	23	0.0481675	0.0566518	0.3951934
Inverse variance weighted	23	-0.0023822	0.0414068	0.9541214
Simple mode	23	0.0631480	0.0994590	0.5320322
Weighted mode	23	0.0357717	0.0684506	0.6064814

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.47119	21	0.2707924
Inverse variance weighted	24.77964	22	0.3077285

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0031336	0.0060908	0.6122866

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000751	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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