Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 78)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0231752	0.1232281	0.8526291
Weighted median	23	0.0124383	0.0548024	0.8204501
Inverse variance weighted	23	-0.0393185	0.0473961	0.4067807
Simple mode	23	0.0139254	0.0856526	0.8723337
Weighted mode	23	0.0100345	0.0616382	0.8721651

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.00366	21	0.0585003
Inverse variance weighted	32.46629	22	0.0697866

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0038377	0.0069654	0.5874709

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010145	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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