Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 778)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0932253	0.1009366	0.3661850
Weighted median	23	0.0145254	0.0566397	0.7976009
Inverse variance weighted	23	0.0539923	0.0407841	0.1855501
Simple mode	23	0.0161790	0.0855774	0.8517819
Weighted mode	23	0.0132293	0.0560802	0.8156928

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.47212	21	0.4304550
Inverse variance weighted	24.03942	22	0.3451665

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0090406	0.0057054	0.1280096

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007864	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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