Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 777)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1174307	0.0998204	0.2525906
Weighted median	23	0.0037685	0.0553056	0.9456748
Inverse variance weighted	23	0.0238351	0.0390157	0.5412580
Simple mode	23	-0.0249375	0.0801797	0.7587129
Weighted mode	23	-0.0132518	0.0697222	0.8510007

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.26743	21	0.8578401
Inverse variance weighted	15.30513	22	0.8488138

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0057477	0.0056424	0.3199502

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004751	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8