Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 776)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1203686	0.0998207	0.2412872
Weighted median	23	-0.0157708	0.0555662	0.7765482
Inverse variance weighted	23	-0.0483366	0.0390156	0.2153803
Simple mode	23	-0.0283177	0.0942589	0.7666737
Weighted mode	23	-0.0030837	0.0667484	0.9635687

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.56541	21	0.6763154
Inverse variance weighted	20.93684	22	0.5246444

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0103601	0.0056423	0.0805359

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006809	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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