Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 775)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0021342	0.1382285	0.9878274
Weighted median	23	-0.0390778	0.0630238	0.5352255
Inverse variance weighted	23	-0.0074161	0.0527923	0.8882836
Simple mode	23	0.0889765	0.1340522	0.5137496
Weighted mode	23	-0.0221733	0.0816904	0.7885906

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.27005	21	0.006894
Inverse variance weighted	40.28085	22	0.010023

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005865	0.0078133	0.9408765

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012217	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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