Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 774)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0808890	0.1354781	0.5568482
Weighted median	23	0.0230048	0.0544217	0.6725046
Inverse variance weighted	23	-0.0303967	0.0527066	0.5641321
Simple mode	23	0.0118971	0.0736542	0.8731528
Weighted mode	23	0.0267294	0.0589021	0.6544229

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.68285	21	0.0107070
Inverse variance weighted	40.14987	22	0.0103839

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.006834	0.0076578	0.3822807

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012349	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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