Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 773)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1376592	0.1141453	0.2412301
Weighted median	23	0.0360418	0.0638093	0.5721856
Inverse variance weighted	23	-0.0022717	0.0453925	0.9600866
Simple mode	23	0.1423445	0.1267678	0.2735954
Weighted mode	23	0.0918425	0.0786281	0.2552844

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.46021	21	0.1561344
Inverse variance weighted	29.77971	22	0.1239176

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0085931	0.006452	0.1971858

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009025	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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