Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 772)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0034410	0.0998211	0.9728265
Weighted median	23	0.0290027	0.0534185	0.5871762
Inverse variance weighted	23	0.0367982	0.0390159	0.3455997
Simple mode	23	0.0300772	0.0813261	0.7150419
Weighted mode	23	0.0300772	0.0601761	0.6221641

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	10.90871	21	0.9645352
Inverse variance weighted	11.10051	22	0.9732854

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0024711	0.0056424	0.6658924

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003633	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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