Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 771)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0586197	0.0998208	0.5632977
Weighted median	23	0.0534872	0.0560883	0.3402739
Inverse variance weighted	23	0.0146103	0.0390158	0.7080539
Simple mode	23	0.0623532	0.0934148	0.5114022
Weighted mode	23	0.0623532	0.0684361	0.3721101

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.10713	21	0.7636021
Inverse variance weighted	16.33656	22	0.7988385

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0027026	0.0056424	0.6368977

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004993	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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