Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 770)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0202355	0.1154835	0.8625818
Weighted median	23	0.0615283	0.0583180	0.2914037
Inverse variance weighted	23	0.0403812	0.0441379	0.3602504
Simple mode	23	0.0702536	0.0987876	0.4844583
Weighted mode	23	0.0405356	0.0621287	0.5208730

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.10802	21	0.1371142
Inverse variance weighted	28.15610	22	0.1705655

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0012371	0.0065277	0.8515027

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008856	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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