Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 77)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1987770	0.1085308	0.0812466
Weighted median	23	0.0581624	0.0593329	0.3269517
Inverse variance weighted	23	0.0446819	0.0437298	0.3068884
Simple mode	23	0.1202285	0.0933710	0.2112513
Weighted mode	23	0.0365923	0.0701919	0.6073539

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.82518	21	0.2548151
Inverse variance weighted	27.63801	22	0.1879900

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.009463	0.0061347	0.1378793

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008772	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8