Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 769)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0046068	0.0998213	0.9636261
Weighted median	23	-0.0416122	0.0520170	0.4237265
Inverse variance weighted	23	-0.0484024	0.0390159	0.2147603
Simple mode	23	-0.0603569	0.0863204	0.4917420
Weighted mode	23	-0.0449619	0.0613131	0.4711078

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	8.731579	21	0.9911732
Inverse variance weighted	9.064435	22	0.9929888

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0032553	0.0056424	0.5701161

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003213	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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