Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 768)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0024734	0.0998205	0.9804652
Weighted median	23	-0.0100601	0.0528768	0.8491086
Inverse variance weighted	23	0.0081736	0.0390159	0.8340632
Simple mode	23	-0.0001742	0.0908503	0.9984871
Weighted mode	23	-0.0350037	0.0637196	0.5883054

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.81114	21	0.8775741
Inverse variance weighted	13.81499	22	0.9079153

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00035	0.0056423	0.9511185

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00042	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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