Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 767)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0880309	0.0998205	0.3878187
Weighted median	23	-0.0485103	0.0554216	0.3814132
Inverse variance weighted	23	-0.0298714	0.0390155	0.4438966
Simple mode	23	-0.0460081	0.0932659	0.6266888
Weighted mode	23	-0.0568443	0.0646418	0.3887033

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	10.60583	21	0.9699239
Inverse variance weighted	11.00651	22	0.9746557

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035716	0.0056424	0.533571

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003513	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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