Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 766)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0360399	0.0998201	0.7216703
Weighted median	23	-0.0052626	0.0530470	0.9209746
Inverse variance weighted	23	-0.0359284	0.0390156	0.3571169
Simple mode	23	-0.0072203	0.0889763	0.9360579
Weighted mode	23	0.0188754	0.0577977	0.7470740

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.88656	21	0.6561716
Inverse variance weighted	18.50010	22	0.6759601

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0044196	0.0056423	0.4422017

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005863	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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