Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 765)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0346596	0.0998209	0.7318834
Weighted median	23	0.0087912	0.0534222	0.8692900
Inverse variance weighted	23	0.0108146	0.0390158	0.7816386
Simple mode	23	-0.0189574	0.0875264	0.8305228
Weighted mode	23	0.0010296	0.0604980	0.9865751

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.39447	21	0.8941799
Inverse variance weighted	13.63942	22	0.9137812

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0027926	0.0056424	0.6257892

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004157	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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