Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 764)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0169373	0.1134368	0.8827336
Weighted median	23	0.0263365	0.0573492	0.6460689
Inverse variance weighted	23	0.0040149	0.0433600	0.9262256
Simple mode	23	0.0230489	0.0925693	0.8056779
Weighted mode	23	-0.0190347	0.0691077	0.7855518

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.12046	21	0.1669015
Inverse variance weighted	27.17246	22	0.2047493

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0012867	0.006412	0.8428902

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008237	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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