Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 763)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1240931	0.1220042	0.3206714
Weighted median	23	0.0344375	0.0583479	0.5550501
Inverse variance weighted	23	0.0925545	0.0466776	0.0473846
Simple mode	23	0.0811881	0.0999469	0.4253155
Weighted mode	23	0.0591369	0.0679331	0.3934179

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.37208	21	0.0676847
Inverse variance weighted	31.48991	22	0.0865180

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019368	0.0068963	0.7815768

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011247	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8