Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 762)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2852442	0.0998200	0.0094264
Weighted median	23	-0.0857876	0.0541757	0.1133061
Inverse variance weighted	23	-0.0686694	0.0390155	0.0783986
Simple mode	23	-0.1173904	0.0850046	0.1811506
Weighted mode	23	-0.1146931	0.0637564	0.0857649

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.47642	21	0.9258547
Inverse variance weighted	18.03265	22	0.7040510

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0132999	0.0056423	0.0281979

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006403	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8