Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 761)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1565071	0.0998205	0.1318538
Weighted median	23	-0.0023655	0.0555370	0.9660258
Inverse variance weighted	23	0.0021816	0.0390157	0.9554083
Simple mode	23	0.0363850	0.0890158	0.6866762
Weighted mode	23	-0.0108382	0.0676235	0.8741289

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.65837	21	0.8396955
Inverse variance weighted	17.64136	22	0.7270277

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.009745	0.0056423	0.0988253

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005347	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8