Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 760)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0038483	0.1173740	0.9741541
Weighted median	23	0.0476016	0.0577944	0.4101462
Inverse variance weighted	23	0.0362493	0.0449177	0.4196578
Simple mode	23	-0.0207682	0.1043895	0.8441296
Weighted mode	23	0.0468911	0.0641792	0.4727172

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.03547	21	0.1131526
Inverse variance weighted	29.15983	22	0.1403540

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019897	0.0066345	0.7671975

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009098	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8