Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 76)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0760382	0.0998201	0.4546784
Weighted median	23	-0.0291426	0.0547465	0.5945050
Inverse variance weighted	23	-0.0244920	0.0390157	0.5301688
Simple mode	23	0.0698879	0.1053303	0.5138962
Weighted mode	23	-0.1234269	0.0803607	0.1388184

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.24502	21	0.8997995
Inverse variance weighted	13.55976	22	0.9163653

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0031655	0.0056423	0.5807217

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004229	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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