Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 759)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0983655	0.1067992	0.3674941
Weighted median	23	0.0101112	0.0583899	0.8625203
Inverse variance weighted	23	0.0091157	0.0419281	0.8278871
Simple mode	23	0.0097638	0.0957995	0.9197444
Weighted mode	23	0.0161278	0.0711404	0.8227473

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.03906	21	0.2911697
Inverse variance weighted	25.40750	22	0.2779874

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0066004	0.0060368	0.2866195

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007715	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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