Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 758)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0421685	0.1130717	0.7129341
Weighted median	23	0.0788795	0.0564803	0.1625387
Inverse variance weighted	23	0.0247577	0.0436018	0.5701614
Simple mode	23	0.1649865	0.1013353	0.1177363
Weighted mode	23	0.1041737	0.0736599	0.1712845

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.94589	21	0.1726515
Inverse variance weighted	27.47647	22	0.1936859

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0041099	0.0063914	0.5271549

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008448	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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