Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 757)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0402851	0.1211175	0.7427251
Weighted median	23	0.0332764	0.0608031	0.5841851
Inverse variance weighted	23	0.0206615	0.0462853	0.6553116
Simple mode	23	-0.1072411	0.1260568	0.4040807
Weighted mode	23	0.0131111	0.0798993	0.8711549

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.91741	21	0.0750436
Inverse variance weighted	30.96302	22	0.0968747

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012051	0.0068462	0.8619623

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009467	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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