Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 756)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0537327	0.0998200	0.5960331
Weighted median	23	0.0437229	0.0552359	0.4286128
Inverse variance weighted	23	0.0464206	0.0390156	0.2341263
Simple mode	23	0.0166308	0.0889516	0.8534023
Weighted mode	23	0.0465772	0.0636819	0.4722514

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.00495	21	0.5848228
Inverse variance weighted	19.01128	22	0.6446318

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.000449	0.0056423	0.937322

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000619	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8