Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 755)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0822481	0.1094334	0.4606439
Weighted median	23	-0.0736856	0.0626313	0.2393958
Inverse variance weighted	23	-0.0471531	0.0419101	0.2605457
Simple mode	23	-0.1091073	0.1200915	0.3734413
Weighted mode	23	-0.1237111	0.0860111	0.1644193

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.24016	21	0.2369126
Inverse variance weighted	25.38606	22	0.2789716

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021552	0.0061857	0.730999

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008135	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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