Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 754)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0108517	0.0998192	0.9144615
Weighted median	23	-0.0787447	0.0571630	0.1683427
Inverse variance weighted	23	-0.0597130	0.0390153	0.1258923
Simple mode	23	-0.0701527	0.0963736	0.4743365
Weighted mode	23	-0.0915939	0.0659952	0.1790682

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.13034	21	0.8163554
Inverse variance weighted	15.41315	22	0.8439061

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030006	0.0056423	0.600444

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000538	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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