Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 753)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0276027	0.1119443	0.8076315
Weighted median	23	-0.0181926	0.0570015	0.7496049
Inverse variance weighted	23	-0.0058610	0.0428554	0.8912185
Simple mode	23	-0.0133143	0.1044425	0.8997190
Weighted mode	23	-0.0266943	0.0654658	0.6873913

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.41103	21	0.1912080
Inverse variance weighted	26.54368	22	0.2290721

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.002055	0.0063277	0.7485712

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000805	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8