Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 752)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1358080	0.0998200	0.1880878
Weighted median	23	-0.0044171	0.0564548	0.9376363
Inverse variance weighted	23	0.0134679	0.0390156	0.7299496
Simple mode	23	-0.0721480	0.1054599	0.5010386
Weighted mode	23	0.0140286	0.0642792	0.8292503

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.48383	21	0.5541332
Inverse variance weighted	21.25680	22	0.5049196

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0075129	0.0056423	0.1972887

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006477	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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