Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 751)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0208395	0.0998200	0.8366386
Weighted median	23	0.0457041	0.0586874	0.4361143
Inverse variance weighted	23	0.0050792	0.0390153	0.8964195
Simple mode	23	0.0898188	0.1191588	0.4589772
Weighted mode	23	0.1151815	0.1082006	0.2986390

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.38878	21	0.6872867
Inverse variance weighted	17.46836	22	0.7370030

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0015917	0.0056424	0.7806317

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005299	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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