Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 750)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0693376	0.1166145	0.5584716
Weighted median	23	0.0180837	0.0544180	0.7396548
Inverse variance weighted	23	-0.0111547	0.0448423	0.8035518
Simple mode	23	0.0271852	0.1010965	0.7905100
Weighted mode	23	0.0157340	0.0616787	0.8010182

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.66053	21	0.1223928
Inverse variance weighted	29.06154	22	0.1431122

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.003573	0.0065916	0.5934874

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008831	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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