Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 75)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0160623	0.1093744	0.8846466
Weighted median	23	0.0018633	0.0572032	0.9740142
Inverse variance weighted	23	-0.0022181	0.0417860	0.9576653
Simple mode	23	-0.0384582	0.0995517	0.7029753
Weighted mode	23	-0.0038325	0.0637018	0.9525689

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.21278	21	0.2380663
Inverse variance weighted	25.23548	22	0.2859469

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0008502	0.0061823	0.891934

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007648	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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