Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 749)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0353277	0.0998212	0.7269355
Weighted median	23	-0.0203492	0.0549321	0.7110531
Inverse variance weighted	23	-0.0361471	0.0390159	0.3542012
Simple mode	23	-0.0458818	0.0950660	0.6341256
Weighted mode	23	-0.0048858	0.0695721	0.9446475

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.12222	21	0.9362595
Inverse variance weighted	12.72736	22	0.9404871

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0043893	0.0056424	0.445299

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004117	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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