Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 748)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0155686	0.0998210	0.8775502
Weighted median	23	0.0344820	0.0561773	0.5393428
Inverse variance weighted	23	0.0470654	0.0390157	0.2276938
Simple mode	23	0.0778742	0.0782981	0.3307516
Weighted mode	23	0.0327521	0.0596297	0.5883608

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.09339	21	0.5791491
Inverse variance weighted	19.21091	22	0.6322712

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0019342	0.0056424	0.7351545

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006262	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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