Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 747)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0733192	0.1139759	0.5270008
Weighted median	23	0.0645602	0.0620290	0.2979654
Inverse variance weighted	23	-0.0121361	0.0442064	0.7836751
Simple mode	23	0.0583384	0.1266152	0.6494976
Weighted mode	23	0.0873341	0.0810441	0.2928819

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.37905	21	0.1586560
Inverse variance weighted	28.24412	22	0.1677312

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0052478	0.0064425	0.4244631

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008588	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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