Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 746)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1584676	0.1031035	0.1392308
Weighted median	23	0.0331827	0.0559784	0.5533310
Inverse variance weighted	23	0.0723736	0.0401363	0.0713573
Simple mode	23	0.1563430	0.0922181	0.1041159
Weighted mode	23	0.0477443	0.0725193	0.5171332

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.40415	21	0.3765503
Inverse variance weighted	23.28217	22	0.3859459

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.005287	0.0058279	0.3745993

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008098	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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