Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 745)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0224224	0.1129117	0.8444984
Weighted median	23	0.0171299	0.0560987	0.7600976
Inverse variance weighted	23	0.0243761	0.0431179	0.5718449
Simple mode	23	0.0325632	0.0838942	0.7016388
Weighted mode	23	0.0225388	0.0635786	0.7263375

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.86903	21	0.1752305
Inverse variance weighted	26.86948	22	0.2162258

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00012	0.0063823	0.9851796

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000826	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8