Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 744)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0484271	0.0998208	0.6325994
Weighted median	23	0.0574342	0.0545076	0.2920247
Inverse variance weighted	23	0.0299410	0.0390157	0.4428382
Simple mode	23	-0.0001891	0.0939006	0.9984109
Weighted mode	23	0.0434460	0.0732027	0.5588979

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.69229	21	0.7866834
Inverse variance weighted	15.73277	22	0.8289236

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0011352	0.0056424	0.84248

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004946	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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